Endocrine Abstracts

Introduction: FSH is a key player in reproductive functions, the expression of its unique subunit FSHB is regulated by the FSHB promoter. Recently, a single nucleotide polymorphism (SNP) at a highly conserved position in the FSHB promoter (rs10835638; −211G>T) has been found to be associated with decreased serum FSH levels in men and with male infertility. Because to date no information is available on possible endocrine consequences of this SNP in women, we conducte...

Background: Recently, a single nucleotide polymorphism (SNP) in the FSHB promoter (−211G>T, rs10835638) was found to be associated with lower serum FSH levels and oligozoospermia in males. In contrast, a SNP in the FSH-receptor gene (FSHR, 2039A>G, rs6166) was previously shown to be associated with FSH levels in women only.Subjects and methods: One thousand two hundred and thirteen male partners in infertile couples without known c...